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By Serge Kreutz (2010)
I have been able to get some pramipexole (Mirapex) tablets. Pramipexole is a second-generation dopaminergic agent that is not ergot-based (bromocriptine and cabergoline are derived from ergot). I have done my usual sexual enhancement tests for pramipexole.
Unfortunately, the results were nowhere as positive as with bromocriptine and cabergoline, or even apomorphine.
A quarter of a 0.125 mg Mirapex tablet only caused slight nausea, even when taken with food, and had no noticeable pro-sexual effect in me. Taking half of a Mirapex tablet (about two hours before sex) only resulted in a more noticeable nausea no better libido, no better erection, and no effect on orgasm.
I combined the Mirapex with Viagra. The nausea was not aggravated, and there was no tachycardia (increased heart rate). The Viagra contributed to the erection, and that was it.
With bromocriptine, I regularly get into a state of mind where I would think: "Oh, boy, I need this so much." With cabergoline, I could go on and on, and have much more powerful ejaculations than when sober.
I can combine 2.5 mg bromocriptine with 0.5 mg cabergoline and have the benefit from both. I tried a quarter of a Mirapex tablet with 2.5 mg of bromocriptine, and just had a slight nausea with the usual positive bromocriptine effect.
I wouldn't know what benefit I derived from pramipexole, alone or in combination with bromocriptine and/or Viagra.
I do recognise that not everybody will react the same way on pramipexole. The following is the assessment of a friend who likewise has many years of experience with dopaminergic agents and yohimbine:
"I take 2 pills, spaced 1 hour apart. When I take them at the same time, my heart starts beating quickly and my blood pressure goes up, so I like to space them out to get a slower onset. I have not read of other people having this problem, so perhaps it is an unusual side effect. I start feeling some sexual effects after one hour, and find the effects are fairly noticeable at 2-4 hours. The effects are definitely enhanced by taking some yohimbe at the same time. However, the yohimbe also increases the heart-rate and blood pressure side effect that I have. With the pramipexole, both erection and sexual sensations are enhanced. When I take 10mg Viagra and pramipexole together, my girlfriend tells me that I feel extremely large and hard to her (even if she doesn't know I've taken them)."
I still have a supply of pramipexole and would like to exchange it for cabergoline.
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Copyright Serge Kreutz